Computational and structural based approach to identify malignant nonsynonymous single nucleotide polymorphisms associated with CDK4 gene.
Cycline-dependent kinase 4 (CDK4), an enzyme of the cycline dependent or Ser/Thr protein kinase family, plays a role in cell cycle progression (G1 phase) by phosphorylating a tumor suppressor protein called pRB.Alteration of this enzyme due Heatshrink to missense mutation/ nonsynonymous single nucleotide polymorphisms (nsSNPs) are responsible for v